Cross-presentation of particulate exogenous antigens (phagosomes)

Regulation of gene expression in early pancreatic precursor cells

Transcription of E2F targets under negative control by DREAM complex

Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)

Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane

TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation

Recognition and association of DNA glycosylase with site containing an affected pyrimidine

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

TFAP2 (AP-2) family regulates transcription of cell cycle factors

IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA

Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus

Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

Thrombin signalling through proteinase activated receptors (PARs)

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation

Defective MTR causes methylmalonic aciduria and homocystinuria type cblG

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

Glutamate binding, activation of AMPA receptors and synaptic plasticity

c-src mediated regulation of Cx43 function and closure of gap junctions

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

L13a-mediated translational silencing of Ceruloplasmin expression

RNA Polymerase III Transcription Initiation From Type 3 Promoter

Transport of Mature mRNA derived from an Intron-Containing Transcript

Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

mitochondrial fatty acid beta-oxidation of unsaturated fatty acids

Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters

Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1

Transport of bile salts and organic acids, metal ions and amine compounds

Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1

Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha

Highly calcium permeable postsynaptic nicotinic acetylcholine receptors

Loss of proteins required for interphase microtubule organization from the centrosome

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)

Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

RNA Polymerase III Transcription Initiation From Type 2 Promoter

Formyl peptide receptors bind formyl peptides and many other ligands

Negative regulation of activity of TFAP2 (AP-2) family transcription factors

Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus

BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members

Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS)

Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits

Orexin and neuropeptides FF and QRFP bind to their respective receptors

Deposition of new CENPA-containing nucleosomes at the centromere

TFAP2 (AP-2) family regulates transcription of other transcription factors

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

Misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling

Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE

Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3

RUNX1 regulates transcription of genes involved in differentiation of HSCs

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding

GLI proteins bind promoters of Hh responsive genes to promote transcription

Negative regulation of TCF-dependent signaling by WNT ligand antagonists

Recognition and association of DNA glycosylase with site containing an affected purine

Resolution of D-loop Structures through Holliday Junction Intermediates

TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2

Ficolins bind to repetitive carbohydrate structures on the target cell surface

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Removal of aminoterminal propeptides from gamma-carboxylated proteins

Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization

Inactivation, recovery and regulation of the phototransduction cascade

HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)

Transport of glycerol from adipocytes to the liver by Aquaporins

Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor

DEx/H-box helicases activate type I IFN and inflammatory cytokines production

RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

Negative regulation of TCF-dependent signaling by DVL-interacting proteins

Inactivation of APC/C via direct inhibition of the APC/C complex

TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Regulation of activated PAK-2p34 by proteasome mediated degradation

RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)

Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)

Gamma-carboxylation, transport, and amino-terminal cleavage of proteins

TFAP2 (AP-2) family regulates transcription of growth factors and their receptors

Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD

Factors involved in megakaryocyte development and platelet production

Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

AXIN mutants destabilize the destruction complex, activating WNT signaling

NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10

IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)

Synthesis of bile acids and bile salts via 27-hydroxycholesterol

RUNX1 regulates transcription of genes involved in WNT signaling

Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation

Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants

Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC

Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

CREB phosphorylation through the activation of Adenylate Cyclase

LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex

Deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint

Synthesis of bile acids and bile salts via 24-hydroxycholesterol

Association of licensing factors with the pre-replicative complex

Recognition of DNA damage by PCNA-containing replication complex

Nef mediated downregulation of MHC class I complex cell surface expression

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

RNA Pol II CTD phosphorylation and interaction with CE during HIV infection

Activation, myristolyation of BID and translocation to mitochondria

RUNX1 regulates transcription of genes involved in BCR signaling

Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal

Association of TriC/CCT with target proteins during biosynthesis

Transport of inorganic cations/anions and amino acids/oligopeptides

Formation of the ternary complex, and subsequently, the 43S complex

Hh mutants that don't undergo autocatalytic processing are degraded by ERAD

Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)

Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Gamma carboxylation, hypusine formation and arylsulfatase activation

Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5)

Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha

Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways

Abasic sugar-phosphate removal via the single-nucleotide replacement pathway

Resolution of AP sites via the multiple-nucleotide patch replacement pathway

Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

RNA Polymerase III Transcription Initiation From Type 1 Promoter

Activation of anterior HOX genes in hindbrain development during early embryogenesis

SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Disassembly of the destruction complex and recruitment of AXIN to the membrane

mitochondrial fatty acid beta-oxidation of saturated fatty acids

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

RUNX1 regulates transcription of genes involved in differentiation of myeloid cells

Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Regulation of mRNA stability by proteins that bind AU-rich elements

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening

JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1

Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)

Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes

Latent infection of Homo sapiens with Mycobacterium tuberculosis

Post-translational modification: synthesis of GPI-anchored proteins

Resolution of AP sites via the single-nucleotide replacement pathway

Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells

Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)

Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2

RNA Polymerase II Transcription Initiation And Promoter Clearance

RUNX1 regulates transcription of genes involved in interleukin signaling